The state is generally divided into Northern and Southern California, although the boundary between the two is not well defined. San Francisco is decidedly a Northern California city and Los Angeles likewise a Southern California one, but areas in between do not often share their confidence in geographic identity. The US Geological Survey defines the geographic center of the state at a point near North Fork, California.

Earth scientists typically divide the state into eleven distinct geomorphic provinces with clearly defined boundaries. They are, from north to south, the Klamath Mountains, the Cascade Range, the Modoc Plateau, the Basin and Range, the Coast Ranges, the Central Valley, the Sierra Nevada, the Transverse Ranges, the Mojave Desert, the Peninsular Ranges, and the Colorado Desert. Here, the Los Angeles Basin, the Channel Islands, and the Pacific Ocean are treated as distinct regions.